Schedule of Didactic Sessions | Session 6
Session 6
Date: Thurs. 4/16/09
Type 1 Diabetes Mellitus: Darrell Wilson, MD
Type 2 Diabetes Mellitus: Tyler Aquinaldo , MD
Topic 1: Type 1 Diabetes
The lecture slides can be found here.
Learning Objectives: After attending this session, the learner should be able to:
- understand the basic functions of the immune system
- understand how abnormal immune function is thought to cause autoimmune disease
- appreciate the roles of genetics and environment in autoimmunity
- understand some immune abnormalities seen in type 1 diabetes and how they result in destruction of pancreatic islet cells
- describe some current immune-based strategies to prevent or treat type 1 diabetes
Key words: immune regulation, cytokines, regulator T cells, MHC
Assignment
- Ermann, J., Fathman, C.G. 2001. Autoimmune diseases: genes, bugs and failed regulation. Nature Immunol. 2(9):759-761.
- Wucherpfennig, K.W., Eisenbarth, G.S. 2001. Type 1 diabetes. Nature Immunol. 2(9):767-768.
- Jaeckel et al. Antigen specific FoxP3 transduced Tcells can control established Type 1 diabetes.Diabetes 2005. 64:306-310.
Supplemental Readings:
School of Medicine Lecture Videos - Etiology Type 1:
Topic 2: Type 2 Diabetes
The lecture slides can be found here.
Learning Objectives:
- understand the pathophysiology of Type 2 diabetes
- explain how patients with Type 2 diabetes are routinely treated
Supplemental Readings:
- Rhoades R and Pflanzer R: Human Physiology. Ch. 15: The endocrine pancreas, pp. 445-458. 3rd ed., Saunders College Publishing/Harcourt Brace College Publishers, Fort Worth. On reserve.