Session 4

Date: Thurs. 4/9/09

Topics and Speakers:

Introduction to Metabolism: Julie Theriot, PhD (Biochemistry; Microbiology and Immunology)

For students with non-medical background:
Introduction to Human Physiology: Dan Garza, MD (Emergency Medicine)

For students with medical background:
Introduction to Engineering: Craig Milroy

Topic 1: Introduction to Metabolism

Download Slides for this session:

Learning Objectives: After attending this topic, the learner should be able to:

define the overall purpose of metabolism
explain why biochemical reactions are linked together into pathways
characterize the sources and storage forms of metabolic energy in humans
describe the effects of blood glucose levels and circulating hormones on metabolism in the liver, skeletal muscle, adipose tissue, heart and brain

Keywords: metabolism, biosynthesis, glucose, glycolysis, gluconeogenesis, glycogen, hyperglycemia

Reading Assignment: None.

Supplementary Resources: (Assigned reading for Session 12)

Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001. 414: 813-820. On-line at http://www.nature.com/nature/journal/v414/n6865/pdf/414813a.pdf

Topic 2: Introduction to Human Physiology

Learning Objectives: After attending this topic, the learner should be able to:

understand the principles of homeostasis and regulation in the body
identify the basic physiologic processes involved in volume regulation
identify acute and chronic medical interventions for disturbances in volume regulatio
provide the definitions of physiology and endocrinology

Keywords: homeostasis, in vivo

Assignment:

Lange Physiology Ch. 19 Endocrine Function of the Pancreas and Regulation of Carbohydrate Metabolism -- Read the remaining sections
Endocrinology An Integrated Approach, by SS Nussey and SA Whitehead: The Endocrine Pancreas -- Read the following sections:
- Glucose Turnover
- Anabolic and Catabolic Phases of Glucose Metabolism
- Actions of Insulin and Glucagon
- Structure, Synthesis and Metabolism of Insulin and Glucagon
- Control of Insulin and Glucagon Secretion,
- Counter-regulatory Hormones and DM

Supplementary Resources:

Rhoades R and Pflanzer R: Human Physiology. Ch. 15: The endocrine pancreas, pp. 445-458. 3rd ed., Saunders College Publishing/Harcourt Brace College Publishers, Fort Worth. On reserve.
Rhoades R and Pflanzer R: Human Physiology. Ch. 1: The science of physiology, pp. 1-26. 3rd ed., Saunders College Publishing/Harcourt Brace College Publishers, Fort Worth. On reserve.
Guyton and Hall. Textbook of Medical Physiology, 10th ed. Saunders, 2003. A classic physiology textbook used by medical students; on the I-Med shelf in Lane Library