Session 10

Date: Thurs. 4/30/09

Topics and Speakers:

Physiology Modeling and hands-on exercise with software, Entelos, Inc., a physiology modeling company

Topic: Physiology Modeling

Learning Objectives: After attending this session, the learner should be able to:

state why glucose homeostasis is important
describe the major processes involved in fasting and non-fasting glucose homeostasis
understand the relationships between plasma glucose levels, secretion of pancreatic hormones, and glucose uptake by target tissues
distinguish between the oral glucose tolerance test of a normal and diabetic patient

Key words: in vivo

Assignment: Review Entelos Virtual Laboratory Exercise (entelos-handout.pdf).

Supplementary Resources

Porte, D., Sherwin, R.S., eds. Diabetes Mellitus, Fifth edition, Appleton & Lange, Stamford, CT. 1997, Ch. 1 Integrated fuel metabolism, pp.1-15. On reserve.
Ho, LX. Biosystems modeling for in silico target validation: challenges to implementation. Emerging Therapeutics Targets. 2000:4(6); 669-714. On reserve.
Prentki M, Tornheim K, Corkey BE. Signal Transduction mechanisms in nutrient induced insulin secretion. Diabetologia. 1997: 40; S32-41.
Pessin JE, Saltiel AR. Signaling pathways in insulin action : molecular targets of insulin resistance. J Clin Invest. 2000: 106(2); 165-169.